Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.32 |
| ▸ | GSK3B | P49841 | 9/20 | 0.32 |
| ▸ | WNT1 | P04628 | 5/20 | 0.32 |
| ▸ | CLK2 | P49760 | 4/20 | 0.32 |
| ▸ | CLK3 | P49761 | 4/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23740976 | 0.87 | HCAR3 (0.33) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23741081 | 0.82 | USP30 (0.35) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23916234 | 0.76 | ABL1 (0.41) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20938979 | 0.74 | DYRK1A (0.38) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23741046 | 0.74 | DYRK1A (0.32) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23740805 | 0.74 | DYRK1A (0.33) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23740875 | 0.74 | DYRK1A (0.32) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL20938783 | 0.73 | DYRK1A (0.32) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23740883 | 0.72 | DYRK1A (0.31) | DYRK1AGSK3BWNT1CLK2CLK3 | |
| SCHEMBL23048847 | 0.71 | HCAR3 (0.33) | DYRK1AGSK3BWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |