Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.53 |
| ▸ | WNT1 | P04628 | 6/20 | 0.53 |
| ▸ | ABL1 | P00519 | 9/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23740948 | 0.95 | GSK3B (0.59) | GSK3BDYRK1AWNT1ABL1JAK2 | |
| SCHEMBL23741017 | 0.94 | GSK3B (0.55) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL23741042 | 0.93 | GSK3B (0.57) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL23741134 | 0.92 | GSK3B (0.56) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL23740823 | 0.90 | GSK3B (0.58) | GSK3BDYRK1AWNT1 | |
| SCHEMBL23741160 | 0.90 | ABL1 (0.51) | GSK3BDYRK1AWNT1ABL1 | |
| SCHEMBL23740792 | 0.89 | DYRK1A (0.60) | GSK3BDYRK1AWNT1 | |
| SCHEMBL23740828 | 0.88 | GSK3B (0.51) | GSK3BDYRK1AWNT1ABL1JAK2 | |
| SCHEMBL24219437 | 0.88 | GSK3B (0.40) | GSK3BDYRK1AWNT1ABL1JAK2 | |
| SCHEMBL23740862 | 0.88 | DYRK1A (0.60) | GSK3BDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |