Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 20/20 | 0.59 |
| ▸ | WNT1 | P04628 | 15/20 | 0.59 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | CLK3 | P49761 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.59 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.59 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.59 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23740922 | 0.81 | GSK3B (0.63) | GSK3BDYRK1AWNT1DYRK3CLK1 | |
| SCHEMBL24219536 | 0.79 | DYRK1A (0.53) | GSK3BDYRK1AWNT1DYRK3CLK1 | |
| SCHEMBL23741226 | 0.79 | GSK3B (0.64) | GSK3BDYRK1AWNT1DYRK3CLK1 | |
| SCHEMBL23740920 | 0.78 | GSK3B (0.61) | GSK3BDYRK1AWNT1DYRK3CLK1 | |
| SCHEMBL23741126 | 0.78 | DYRK1A (0.56) | GSK3BDYRK1AWNT1CLK2CLK3 | |
| SCHEMBL23740979 | 0.77 | GSK3B (0.58) | GSK3BDYRK1AWNT1 | |
| SCHEMBL23741058 | 0.76 | GSK3B (0.61) | GSK3BDYRK1AWNT1DYRK3CLK1 | |
| SCHEMBL23740765 | 0.76 | GSK3B (0.61) | GSK3BDYRK1AWNT1DYRK3CLK1 | |
| SCHEMBL24219615 | 0.75 | GSK3B (0.37) | GSK3BDYRK1AWNT1 | |
| SCHEMBL20938540 | 0.75 | DYRK1A (0.43) | GSK3BDYRK1AWNT1CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |