Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 3/20 | 0.67 |
| ▸ | GSK3B | P49841 | 3/20 | 0.67 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.42 |
| ▸ | FECH | P22830 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19515643 | 0.82 | GSK3B (0.72) | WNT1GSK3BDYRK1A | |
| SCHEMBL19516467 | 0.82 | GSK3B (0.69) | WNT1GSK3BDYRK1A | |
| SCHEMBL30004474 | 0.82 | GSK3B (0.69) | WNT1GSK3BDYRK1A | |
| SCHEMBL28221232 | 0.81 | WNT1 (0.49) | WNT1GSK3BDYRK1ACHEK1MKNK1 | |
| SCHEMBL28895474 | 0.81 | GSK3B (0.70) | WNT1GSK3BDYRK1A | |
| SCHEMBL30005747 | 0.81 | GSK3B (1.00) | WNT1GSK3BDYRK1A | |
| SCHEMBL19515437 | 0.81 | GSK3B (1.00) | WNT1GSK3BDYRK1A | |
| SCHEMBL19515466 | 0.80 | GSK3B (0.74) | WNT1GSK3BDYRK1A | |
| SCHEMBL19516224 | 0.80 | GSK3B (0.69) | WNT1GSK3BDYRK1A | |
| SCHEMBL28895344 | 0.80 | GSK3B (0.69) | WNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3448838-B1 | ISOQUINOLIN-3-YL CARBOXAMIDES AND PREPARATION AND USE THEREOF | BIOSPLICE THERAPEUTICS INC (US) | 2021-08-11 | — | — | EP | disclosed |