Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
| ▸ | CES1 | P23141 | 4/20 | 0.52 |
| ▸ | CES2 | O00748 | 3/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL27934776 | 0.91 | TSHR (0.57) | TSHRDAONAPRTCES1CES2 | |
| Terephthalic Acid SCHEMBL11409303 | 0.91 | TSHR (0.57) | TSHRDAONAPRTCES1CES2 | |
| Isophthalic Acid SCHEMBL9935747 | 0.88 | CA12 (0.50) | TSHRDAONAPRTHPGDTDP1 | |
| Benzoic Acid SCHEMBL1131222 | 0.88 | DAO (0.47) | TSHRDAONAPRTCES1CES2 | |
| Benzophenone SCHEMBL9545189 | 0.87 | ALDH1A1 (0.61) | CES1SRD5A2PTPN1GSK3BKMT2A | |
| Benzoic Acid SCHEMBL9347407 | 0.84 | TSHR (0.78) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL207614 | 0.84 | TSHR (0.78) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL1254290 | 0.84 | TSHR (0.78) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL2779805 | 0.84 | TSHR (0.78) | TSHRDAONAPRTCES1CES2 | |
| Benzoic Acid SCHEMBL27410268 | 0.84 | TSHR (0.78) | TSHRDAONAPRTCES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116655282-B | Ocean engineering chloride ion resistant agent and preparation method thereof | 日照市海洋工程研究院 | 2024-02-27 | — | — | CN | claimed |
| CN-116655282-A | Ocean engineering chloride ion resistant agent and preparation method thereof | 日照市海洋工程研究院 | 2023-08-29 | — | — | CN | claimed |
| CN-114716990-B | Oilfield high Wen Fanggou corrosion inhibitor and preparation method thereof | 中海油(天津)油田化工有限公司 | 2023-07-28 | — | — | CN | claimed |
| CN-113862072-B | Water-based antirust agent for tempering process of bearing ring | 南京科润工业介质股份有限公司 | 2022-11-04 | — | — | CN | claimed |
| CN-114716990-A | High-temperature scale and corrosion inhibitor for oil field and preparation method thereof | 中海油(天津)油田化工有限公司 | 2022-07-08 | — | — | CN | claimed |
| CN-114431231-A | Low-irritation low-corrosivity organic chlorine disinfectant and preparation method and application thereof | 广州迈高化学有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-114316903-A | Environment-friendly quick-acting snow-melting agent | 杨毅男 | 2022-04-12 | — | — | CN | claimed |
| CN-114150504-A | Preparation method of antirust cover | 安徽马钢和菱实业有限公司 | 2022-03-08 | — | — | CN | claimed |
| CN-113913838-A | Polyimide rust remover, preparation method thereof and rust piece rust removing method | 成都普利美特科技有限公司 | 2022-01-11 | — | — | CN | claimed |
| EP-0086994-B1 | KARL FISCHER REAGENT AND METHOD FOR THE DETERMINATION OF WATER USING THIS REAGENT | MERCK PATENT GmbH (DE) | 1987-01-07 | — | — | EP | claimed |
| US-4550083-A | Karl-Fischer reagent and procedure for the determination of water using it | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-29 | — | — | US | claimed |
| EP-0086994-A1 | Karl Fischer reagent and method for the determination of water using this reagent | MERCK PATENT GmbH (DE) | 1983-08-31 | — | — | EP | claimed |
| CN-116655282-B | Ocean engineering chloride ion resistant agent and preparation method thereof | 日照市海洋工程研究院 | 2024-02-27 | — | — | CN | disclosed |
| CN-114150504-B | Preparation method of rust-proof cover | 安徽马钢和菱实业有限公司 | 2024-01-30 | — | — | CN | disclosed |
| CN-116655282-A | Ocean engineering chloride ion resistant agent and preparation method thereof | 日照市海洋工程研究院 | 2023-08-29 | — | — | CN | disclosed |
| CN-114716990-B | Oilfield high Wen Fanggou corrosion inhibitor and preparation method thereof | 中海油(天津)油田化工有限公司 | 2023-07-28 | — | — | CN | disclosed |
| US-4752340-A | SURFACE TREATMENT WITH AN AMINE SALT OF A POLYPROTIC ACID | KERR-MCGEE CHEMICAL CORPORATION (US) | 1988-06-21 | — | — | US | disclosed |
| EP-0086994-B1 | KARL FISCHER REAGENT AND METHOD FOR THE DETERMINATION OF WATER USING THIS REAGENT | MERCK PATENT GmbH (DE) | 1987-01-07 | — | — | EP | disclosed |
| US-4550083-A | Karl-Fischer reagent and procedure for the determination of water using it | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-10-29 | — | — | US | disclosed |
| EP-0086994-A1 | Karl Fischer reagent and method for the determination of water using this reagent | MERCK PATENT GmbH (DE) | 1983-08-31 | — | — | EP | disclosed |