SCHEMBL23743538

CC[C@@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)CSC[C@@H](C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CC/C(C)=N\OC(C)C)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)N(C)C(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@H](C)N(C)COC[C@H](Cc2ccc(-c3ccccc3)cc2)NC1=O

nearest known ligand 0.43

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	KEAP1	Q14145	1/20	0.43

▸	NFE2L2	Q16236	1/20	0.43

▸	KLKB1	P03952	6/20	0.42

▸	KLK5	Q9Y337	4/20	0.41

▸	ALB	P02768	2/20	0.41

▸	CD274	Q9NZQ7	2/20	0.40

▸	PLAU	P00749	1/20	0.40

▸	EPHA2	P29317	1/20	0.39

▸	CIB1	Q99828	1/20	0.39

▸	SLC40A1	Q9NP59	1/20	0.39

▸	SLC6A3	Q01959	1/20	0.39

▸	PIN1	Q13526	2/20	0.39

▸	PDCD1	Q15116	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL23743518	0.89	KLKB1 (0.46)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL26951743	0.88	KLKB1 (0.49)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL26952071	0.86	KEAP1 (0.51)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL23743537	0.86	KLKB1 (0.48)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL26952055	0.85	KLKB1 (0.48)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL23743610	0.85	KLK5 (0.49)	KLKB1KLK5ALBPLAUPIN1
SCHEMBL26951558	0.85	KLKB1 (0.47)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL26951937	0.84	KLKB1 (0.47)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL26951915	0.82	KEAP1 (0.49)	KEAP1NFE2L2KLKB1KLK5ALB
SCHEMBL26951725	0.82	KEAP1 (0.41)	KEAP1NFE2L2KLKB1KLK5ALB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2021156792-A1	TARGETED PLASMA PROTEIN DEGRADATION	NOVARTIS AG (CH)	2021-08-12	—	—	WO	disclosed