Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374433 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2POLBKDM4EMEN1KMT2A | |
| SCHEMBL2376389 | 0.87 | POLB (0.65) | POLBMEN1KMT2AFAAH | |
| SCHEMBL2376394 | 0.87 | POLB (0.65) | POLBMEN1KMT2AFAAH | |
| SCHEMBL2376376 | 0.85 | POLB (0.51) | SMN1; SMN2POLBKDM4EMEN1KMT2A | |
| SCHEMBL2376370 | 0.85 | POLB (0.51) | SMN1; SMN2POLBKDM4EMEN1KMT2A | |
| SCHEMBL12139200 | 0.83 | ALDH1A1 (0.56) | SMN1; SMN2KDM4ECYP1A2CYP2D6MAPT | |
| SCHEMBL19290046 | 0.81 | POLB (0.63) | POLBMEN1KMT2AFAAH | |
| SCHEMBL2374673 | 0.79 | POLB (0.51) | POLBMEN1KMT2A | |
| SCHEMBL2374680 | 0.79 | POLB (0.51) | POLBMEN1KMT2A | |
| SCHEMBL16254373 | 0.79 | POLB (0.66) | POLBMEN1KMT2AFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224210-A1 | NOVEL BIS-AMIDES AS ANTI-MALARIAL AGENTS | CTSA, BECN1, HDAC6 | SMN1; SMN2 4567/4885POLB 1882/4885KDM4E 1004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.