Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.39 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.39 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25162945 | 0.90 | MEN1 (0.44) | POLBCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23744343 | 0.90 | RAB9A (0.41) | NPC1RAB9AKMT2AMEN1MAPK1 | |
| SCHEMBL25162946 | 0.86 | IRAK4 (0.40) | POLBCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL23744365 | 0.82 | HTT (0.40) | NPC1RAB9AIRAK4 | |
| SCHEMBL25162450 | 0.80 | MAPT (0.44) | CYP1A2CYP3A4CYP2C19NPC1RAB9A | |
| SCHEMBL23806215 | 0.80 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL23806372 | 0.80 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL23744363 | 0.80 | IRAK4 (0.54) | IRAK4 | |
| SCHEMBL22849583 | 0.79 | IRAK4 (0.57) | IRAK4 | |
| SCHEMBL23744364 | 0.77 | MEN1 (0.52) | IRAK4KMT2AMEN1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158634-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |