Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | TYK2 | P29597 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23744679 | 0.87 | HTR2A (0.46) | HTR2AHTR2CHTR2BCHRM4KDM1A | |
| SCHEMBL26087038 | 0.87 | HTR2A (0.46) | HTR2AHTR2CHTR2BCHRM4KDM1A | |
| SCHEMBL23232139 | 0.72 | IRAK4 (0.40) | HTR2AHTR2CHTR2BJAK2JAK1 | |
| SCHEMBL23744326 | 0.71 | ROCK2 (0.41) | HTR2AHTR2CHTR2BJAK2JAK1 | |
| SCHEMBL23744678 | 0.71 | ROCK2 (0.41) | HTR2AHTR2CHTR2BJAK2JAK1 | |
| SCHEMBL2224273 | 0.71 | KDM4E (0.50) | HTR2AHTR2CHTR2BCHRM1JAK2 | |
| SCHEMBL23744494 | 0.69 | CHRM4 (0.32) | CHRM4KDM1ACHRM5CHRM1CHRM3 | |
| SCHEMBL23744665 | 0.65 | ROCK2 (0.39) | CHRM4KDM1ACHRM5CHRM1CHRM3 | |
| SCHEMBL23744666 | 0.65 | ROCK2 (0.39) | CHRM4KDM1ACHRM5CHRM1CHRM3 | |
| SCHEMBL23744674 | 0.65 | ROCK2 (0.39) | CHRM4KDM1ACHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021158698-A1 | MUSCARINIC RECEPTOR 4 ANTAGONISTS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-08-12 | — | — | WO | disclosed |