⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23025945 | 0.84 | — | — | |
| SCHEMBL15883901 | 0.78 | — | — | |
| SCHEMBL26669855 | 0.74 | — | — | |
| SCHEMBL14996662 | 0.73 | — | — | |
| SCHEMBL23026109 | 0.71 | — | — | |
| SCHEMBL23729121 | 0.70 | LMNA (0.40) | — | |
| SCHEMBL21610973 | 0.70 | LRRK2 (0.42) | — | |
| SCHEMBL23729119 | 0.66 | LRRK2 (0.46) | — | |
| SCHEMBL23729120 | 0.66 | NPSR1 (0.32) | — | |
| SCHEMBL21720897 | 0.64 | LRRK2 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667634-B2 | Inhibitors of RAF kinases | KINNATE BIOPHARMA INC. (US) | 2023-06-06 | — | — | US | disclosed |
| WO-2022109001-A1 | GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF | DECIPHERA PHARMACEUTICALS, LLC (US) | 2022-05-27 | — | — | WO | disclosed |
| US-20210246135-A1 | INHIBITORS OF RAF KINASES | Pierre Fabre Médicament (FR) | 2021-08-12 | — | — | US | disclosed |