Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.59 |
| ▸ | MMP13 | P45452 | 10/20 | 0.58 |
| ▸ | MMP2 | P08253 | 10/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.56 |
| ▸ | MMP14 | P50281 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MMP3 | P08254 | 2/20 | 0.53 |
| ▸ | MMP12 | P39900 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31121172 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL23745283 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL23745208 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL31121170 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL23745210 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL23728086 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL23745286 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL23745207 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL31121196 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 | |
| SCHEMBL30013188 | 1.00 | ADAMTS5 (0.59) | ADAMTS5MMP13MMP2ADAM17ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052596-B | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-115052596-A | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-09-13 | — | — | CN | disclosed |
| WO-2021158626-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Eternity Bioscience Inc. (US) | 2021-08-12 | — | — | WO | disclosed |