Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.58 |
| ▸ | ADAMTS4 | O75173 | 8/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.56 |
| ▸ | MMP2 | P08253 | 3/20 | 0.53 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP12 | P39900 | 1/20 | 0.53 |
| ▸ | MMP14 | P50281 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29250271 | 1.00 | ADAMTS5 (0.58) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL29835207 | 1.00 | ADAMTS5 (0.58) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL29835187 | 0.90 | ADAMTS5 (0.65) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL23727487 | 0.90 | ADAMTS5 (0.65) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL23727486 | 0.90 | ADAMTS5 (0.65) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL23745216 | 0.87 | ADAMTS5 (0.61) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL29250263 | 0.87 | ADAMTS5 (0.61) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL29835148 | 0.87 | ADAMTS5 (0.61) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL23745236 | 0.85 | ADAMTS5 (0.59) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 | |
| SCHEMBL23745241 | 0.85 | ADAMTS5 (0.59) | ADAMTS5ADAMTS4ADAM17MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052596-B | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2021158626-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Eternity Bioscience Inc. (US) | 2021-08-12 | — | — | WO | disclosed |