Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 18/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 10/20 | 0.53 |
| ▸ | MMP2 | P08253 | 7/20 | 0.53 |
| ▸ | MMP13 | P45452 | 6/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.53 |
| ▸ | MMP1 | P03956 | 3/20 | 0.53 |
| ▸ | MMP3 | P08254 | 3/20 | 0.53 |
| ▸ | MMP7 | P09237 | 3/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.53 |
| ▸ | MMP14 | P50281 | 3/20 | 0.53 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.50 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30012955 | 1.00 | ADAMTS5 (0.53) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL30899243 | 1.00 | ADAMTS5 (0.53) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL31121175 | 1.00 | ADAMTS5 (0.53) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23745439 | 1.00 | ADAMTS5 (0.53) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23728103 | 1.00 | ADAMTS5 (0.53) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23745269 | 0.85 | ADAMTS5 (0.43) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23745271 | 0.85 | ADAMTS5 (0.43) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23745259 | 0.85 | ADAMTS5 (0.43) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL23727860 | 0.84 | ADAMTS5 (0.58) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 | |
| SCHEMBL29835135 | 0.84 | ADAMTS5 (0.58) | ADAMTS5ADAM17MMP2MMP13ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113754635-B | Condensed ring compound and preparation method and application thereof | 成都康弘药业集团股份有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-115052596-B | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2024-06-14 | — | — | CN | disclosed |
| CN-115052596-A | ADAMTS inhibitor, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-09-13 | — | — | CN | disclosed |
| WO-2021158626-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Eternity Bioscience Inc. (US) | 2021-08-12 | — | — | WO | disclosed |