SCHEMBL23745954

SCHEMBL23745954

Nc1ccccc1NC(=O)c1cnc(NC(=O)c2ccccc2)cn1

nearest known ligand 0.68

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 14/20 0.68
HDAC3 O15379 13/20 0.68
HDAC2 Q92769 9/20 0.68
HDAC8 Q9BY41 7/20 0.68
HDAC6 Q9UBN7 5/20 0.68
NCOR1 O75376 3/20 0.68
MAPK1 P28482 1/20 0.66
HDAC4 P56524 3/20 0.56
HDAC7 Q8WUI4 3/20 0.56
HDAC10 Q969S8 3/20 0.56
HDAC11 Q96DB2 3/20 0.56
HDAC9 Q9UKV0 3/20 0.56
HDAC5 Q9UQL6 3/20 0.56
NCOR2 Q9Y618 1/20 0.56
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
PTGS1 P23219 1/20 0.50
HCAR3 P49019 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23745951 0.83 HDAC3 (0.73) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL23745938 0.83 HDAC3 (0.63) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL23745968 0.82 HDAC3 (0.61) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL407834 0.81 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL30363156 0.81 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL23746023 0.81 HDAC1 (1.00) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL23745956 0.81 HDAC3 (0.64) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL23745937 0.81 HDAC3 (0.60) HDAC1HDAC3HDAC2HDAC8HDAC6
SCHEMBL1063809 0.80 HDAC1 (0.65) HDAC1HDAC3HDAC2HDAC8HDAC6
Hydrochloric Acid SCHEMBL2828661 0.80 HDAC1 (0.96) HDAC1HDAC3HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021158869-A1 COMPOUNDS, COMPOSITIONS, METHODS FOR TREATING DISEASES AND NERVE DAMAGE, AND METHODS FOR PREPARING COMPOUNDS CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2021-08-12 WO disclosed