Sugi Predict

Sugi Predict / Compounds / SCHEMBL407834

SCHEMBL407834

SCHEMBL407834

Nc1ccccc1NC(=O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ HDAC1 Q13547 16/20 1.00
▸ HDAC3 O15379 10/20 1.00
▸ HDAC2 Q92769 10/20 1.00
▸ MAPK1 P28482 1/20 1.00
▸ NCOR2 Q9Y618 5/20 0.80
▸ NPC1 O15118 1/20 0.74
▸ RAB9A P51151 1/20 0.74
▸ PTGS1 P23219 2/20 0.70
▸ HDAC4 P56524 1/20 0.68
▸ HDAC7 Q8WUI4 1/20 0.68
▸ HDAC10 Q969S8 1/20 0.68
▸ HDAC11 Q96DB2 1/20 0.68
▸ HDAC8 Q9BY41 1/20 0.68
▸ HDAC6 Q9UBN7 1/20 0.68
▸ HDAC9 Q9UKV0 1/20 0.68
▸ HDAC5 Q9UQL6 1/20 0.68
▸ MDM4 O15151 1/20 0.61
▸ TP53 P04637 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30363156 1.00 HDAC1 (1.00) HDAC1HDAC3HDAC2MAPK1NCOR2
Hydrochloric Acid SCHEMBL2828661 0.98 HDAC1 (0.96) HDAC1HDAC3HDAC2MAPK1NCOR2
SCHEMBL8401704 0.94 HDAC1 (0.89) HDAC1HDAC3HDAC2MAPK1NCOR2
SCHEMBL23500754 0.91 HDAC1 (0.83) HDAC1HDAC3HDAC2MAPK1NCOR2
Dinaline SCHEMBL29354254 0.89 HDAC1 (0.79) HDAC1HDAC3HDAC2MAPK1NCOR2
Dinaline SCHEMBL93636 0.89 HDAC1 (0.79) HDAC1HDAC3HDAC2MAPK1NCOR2
SCHEMBL1060598 0.89 HDAC1 (0.79) HDAC1HDAC3HDAC2MAPK1NCOR2
SCHEMBL8403312 0.89 HDAC1 (0.79) HDAC1HDAC3HDAC2MAPK1NCOR2
Dinaline SCHEMBL21797218 0.87 HDAC1 (0.76) HDAC1HDAC3HDAC2MAPK1NCOR2
Dinaline SCHEMBL10373837 0.87 HDAC1 (0.77) HDAC1HDAC3HDAC2MAPK1NCOR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 175 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119306700-A DNMT1-HDAC double-target inhibitor and preparation method and application thereof 山东大学 2025-01-14 — — CN claimed
CN-116903581-A SHP2/HDAC double-target inhibitor and preparation method and application thereof 山东大学 2023-10-20 — — CN claimed
US-20230084927-A1 GLUCOSE UPTAKE INHIBITORS AND USES THEREOF METABOMED LTD. (IL) 2023-03-16 — — US claimed
CN-115108930-A Synthetic method and application of aminophenyl benzamide compound 合肥工业大学 2022-09-27 — — CN claimed
EP-4058027-A1 GLUCOSE UPTAKE INHIBITORS AND USES THEREOF Metabomed Ltd (IL) 2022-09-21 — — EP claimed
US-20220133892-A1 Chimeric Compounds and Methods of Managing Neurological Disorders or Conditions UNIV EMORY (US) 2022-05-05 — — US claimed
WO-2021095032-A1 GLUCOSE UPTAKE INHIBITORS AND USES THEREOF METABOMED LTD (IL) 2021-05-20 — — WO claimed
EP-3062784-B1 ANTIMICROBIAL COMPOUNDS AKTHELIA PHARMACEUTICALS (IS) 2020-12-23 — — EP claimed
CN-105682655-B Antimicrobial compounds 阿克塞利亚制药公司 2020-03-27 — — CN claimed
US-9957226-B2 Antimicrobial compounds AKTHELIA PHARMACEUTICALS (IS) 2018-05-01 — — US claimed
US-20160257642-A1 ANTIMICROBIAL COMPOUNDS AKTHELIA PHARMACEUTICALS (IS) 2016-09-08 — — US claimed
CN-105682655-A Antimicrobial compounds 阿克塞利亚制药公司 2016-06-15 — — CN claimed
CN-1015417-B PROCESS FOR PREPARING MEDICINE COMBINATION CONTAINING FORMAMIDE DERIVATIVES GOEDECKE AG (DE) 1992-02-12 — — CN claimed
CN-1048321-A The preparation of drug combination method that contains heterocyclic carbamate derivatives GOEDECKE AG (DE) 1991-01-09 — — CN claimed
US-3961884-A Process for dyeing textile material of polyester fiber/cellulose blends HOECHST AKTIENGESELLSCHAFT (DT) 1976-06-08 — — US claimed
JP-4247080-A — — None — — JP disclosed
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions EMORY UNIVERSITY (US) 2026-03-24 — — US disclosed
US-3961887-A Process for the printing of cellulose containing textile material HOECHST AKTIENGESELLSCHAFT (DT) 1976-06-08 — — US disclosed
US-3961884-A Process for dyeing textile material of polyester fiber/cellulose blends HOECHST AKTIENGESELLSCHAFT (DT) 1976-06-08 — — US disclosed
US-3951941-A POLYAZODYE SAKAI CHEMICAL INDUSTRY COMPANY, LIMITED (JA) 1976-04-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220133892-A1 Chimeric Compounds and Methods of Managing Neurological Disorders or Conditions MAOA, HNMT, HDAC6 HDAC1 12/4885HDAC3 46/4885HDAC2 34/4885
US-20160257642-A1 ANTIMICROBIAL COMPOUNDS BECN1, SQSTM1, ATG7 HDAC1 16/4885HDAC3 4/4885HDAC2 23/4885
US-20230084927-A1 GLUCOSE UPTAKE INHIBITORS AND USES THEREOF SLC2A4, SLC2A1, SLC2A2 HDAC1 1975/4885HDAC3 2625/4885HDAC2 975/4885
US-12582719-B2 Chimeric compounds and methods of managing neurological disorders or conditions SLC6A4, HTR4, HTR1A HDAC1 101/4885HDAC3 153/4885HDAC2 131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.