Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.46 |
| ▸ | NR2C2 | P49116 | 3/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.46 |
| ▸ | RELA | Q04206 | 3/20 | 0.46 |
| ▸ | TAB1 | Q15750 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31681841 | 0.88 | AURKA (0.48) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL2373417 | 0.88 | AURKA (0.48) | JAK2JAK1TYK2JAK3CDK2 | |
| SCHEMBL2375787 | 0.88 | NFKB1 (0.50) | MKNK1MKNK2NFKB1NR2C2NFKB2 | |
| SCHEMBL21651044 | 0.88 | TYK2 (0.40) | MKNK1MKNK2NFKB1NR2C2NFKB2 | |
| SCHEMBL2374950 | 0.86 | TYK2 (0.47) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL31681839 | 0.86 | JAK1 (0.44) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2375105 | 0.86 | JAK1 (0.44) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL2373916 | 0.84 | ROCK1 (0.43) | NFKB1NR2C2NFKB2RELATAB1 | |
| SCHEMBL2373964 | 0.84 | ROCK1 (0.48) | MKNK1MKNK2CDK2AURKASYK | |
| SCHEMBL31681831 | 0.84 | ROCK1 (0.48) | MKNK1MKNK2CDK2AURKASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12410397-B2 | Methods of enhancing cell survival of stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2025-09-09 | — | — | US | disclosed |
| EP-4585589-A2 | STEM CELL CULTURES | The Scripps Research Institute (US) | 2025-07-16 | — | — | EP | disclosed |
| EP-4296270-B1 | A COMPOSITION COMPRISING STEM CELL CULTURES | SCRIPPS RESEARCH INST (US) | 2025-06-18 | — | — | EP | disclosed |
| EP-4296270-A2 | A COMPOSITION COMPRISING STEM CELL CULTURES | The Scripps Research Institute (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3936508-B1 | A COMPOSITION COMPRISING STEM CELL CULTURES | SCRIPPS RESEARCH INST (US) | 2023-12-06 | — | — | EP | disclosed |
| EP-3936508-A1 | A COMPOSITION COMPRISING STEM CELL CULTURES | The Scripps Research Institute (US) | 2022-01-12 | — | — | EP | disclosed |
| EP-3936508-A1 | A COMPOSITION COMPRISING STEM CELL CULTURES | The Scripps Research Institute (US) | 2022-01-12 | — | — | EP | disclosed |
| US-20210403862-A1 | METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE | 2021-12-30 | — | — | US | disclosed |
| US-20210403862-A1 | METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS | THE SCRIPPS RESEARCH INSTITUTE | 2021-12-30 | — | — | US | disclosed |
| EP-3623374-B1 | STEM CELL CULTURES | SCRIPPS RESEARCH INST (US) | 2021-09-08 | — | — | EP | disclosed |
| US-20110294761-A1 | STEM CELL CULTURES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294761-A1 | STEM CELL CULTURES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294761-A1 | STEM CELL CULTURES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-12-01 | — | — | US | disclosed |
| US-8044201-B2 | Stem cell cultures | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-10-25 | — | — | US | disclosed |
| US-8044201-B2 | Stem cell cultures | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-10-25 | — | — | US | disclosed |
| US-8044201-B2 | Stem cell cultures | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-10-25 | — | — | US | disclosed |
| US-20110224233-A1 | STEM CELL CULTURES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224233-A1 | STEM CELL CULTURES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110224233-A1 | STEM CELL CULTURES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-09-15 | — | — | US | disclosed |
| WO-2010065721-A1 | STEM CELL CULTURES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294761-A1 | STEM CELL CULTURES | NES, CD44, MCL1 | MKNK1 2205/4885MKNK2 2167/4885NFKB1 2605/4885 |
| US-12410397-B2 | Methods of enhancing cell survival of stem cells | MCL1, BCL2, BCLAF1 | MKNK1 2355/4885MKNK2 2333/4885NFKB1 2174/4885 |
| US-20210403862-A1 | METHODS OF ENHANCING CELL SURVIVAL OF STEM CELLS | MCL1, BCL2, BCLAF1 | MKNK1 2355/4885MKNK2 2333/4885NFKB1 2174/4885 |
| US-20110224233-A1 | STEM CELL CULTURES | NES, CD44, MCL1 | MKNK1 2205/4885MKNK2 2167/4885NFKB1 2605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.