Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 5/20 | 0.57 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.56 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.56 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17916794 | 0.88 | SMN1; SMN2 (0.88) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23747838 | 0.86 | SMN1; SMN2 (0.65) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23747492 | 0.84 | LSS (0.76) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL23747454 | 0.84 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23747822 | 0.83 | SMN1; SMN2 (0.75) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23747485 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23728203 | 0.82 | SMN1; SMN2 (0.79) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23747473 | 0.82 | SMN1; SMN2 (0.79) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9836017 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23728131 | 0.82 | SMN1; SMN2 (0.73) | SMN1; SMN2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021159015-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-08-12 | — | — | WO | disclosed |