SCHEMBL2374780

SCHEMBL2374780

C=Cc1ccc(NC)cc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.58
APP P05067 9/20 0.56
KCNH2 Q12809 2/20 0.44
TSHR P16473 2/20 0.43
HDAC8 Q9BY41 1/20 0.42
RECQL P46063 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TDP1 Q9NUW8 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
TP53 P04637 1/20 0.38
CYP3A4 P08684 1/20 0.38
THRB P10828 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
CASP1 P29466 1/20 0.38
HIF1A Q16665 1/20 0.38
MAT2A P31153 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1934708 0.97 ALDH1A1 (0.55) ALDH1A1APPKCNH2TSHRHDAC8
SCHEMBL21475272 0.93 APP (0.50) ALDH1A1APPKCNH2TSHRHDAC8
Styrene SCHEMBL10628468 0.83 ALDH1A1 (0.64) ALDH1A1APPKCNH2TSHRHDAC8
SCHEMBL15087416 0.78 APP (0.41) ALDH1A1APPKCNH2TDP1TP53
SCHEMBL9680312 0.78 APP (0.77) APPKCNH2TSHRMAT2A
SCHEMBL19003408 0.78 APP (0.77) APPKCNH2TSHRMAT2A
SCHEMBL900823 0.78 APP (0.77) APPKCNH2TSHRMAT2A
SCHEMBL9678907 0.78 APP (0.77) APPKCNH2TSHRMAT2A
SCHEMBL1697678 0.78 ALDH1A1 (0.65) ALDH1A1APPTSHRHDAC8RECQL
SCHEMBL11563830 0.78 ALDH1A1 (0.65) ALDH1A1APPTSHRHDAC8RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8192717-B2 Flavone derivative, chalcone derivative, styrylchromone derivative, or a coumarin derivative with high binding specificity to an amyloid beta protein, high permeability to a blood-brain barrier, and ability to rapidly disappear from sites other than cerebral senile plaque; also drug screening NAGASAKI UNIVERSITY (JP) 2012-06-05 US claimed
US-20080131367-A1 Composition For Diagnosing Amyloid-Related Diseases Mori, Hiroshi (JP) 2008-06-05 US claimed
EP-1815872-A1 COMPOSITION FOR AMYLOID-ASSOCIATED DISEASE DIAGNOSIS Nagasaki University (JP) 2007-08-08 EP claimed
CN-119585610-A Reagent layer and biosensor comprising the same 普和希控股公司 2025-03-07 CN disclosed
CN-118843620-A Electron acceptor, and reagent layer and sensor using the same 普和希控股公司 2024-10-25 CN disclosed
CN-117616056-A Polymer, reagent layer and sensor 普和希控股公司 2024-02-27 CN disclosed
CN-117466803-A Compounds, salts thereof and methods for treating diseases 阿卡蒂亚药品公司 2024-01-30 CN disclosed
US-20230359119-A1 RESIST COMPOSITION AND PATTERN FORMING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-11-09 US disclosed
CN-111132976-B Compounds, salts thereof and methods for treating diseases 阿卡蒂亚药品公司 2023-08-22 CN disclosed
CN-111909083-B Inhibitors of histone demethylase 赛尔基因昆蒂赛尔研究公司 2023-08-15 CN disclosed
CN-116410370-A Metallocene catalyst for ethylene polymerization and application thereof 中国石油天然气股份有限公司 2023-07-11 CN disclosed
US-4761358-A Electrostatographic encapsulated toner FUJI PHOTO FILM CO., LTD. (JP) 1988-08-02 US disclosed
US-4701420-A Analytical compositions, elements and methods utilizing reduction of ferric ion chelates to form detectable dyes EASTMAN KODAK COMPANY (US) 1987-10-20 US disclosed
EP-0009411-B2 PHOTOGRAPHIC RECORDING MATERIAL CONTAINING POLYMERS WHICH COORDINATE WITH METAL IONS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1986-11-26 EP disclosed
EP-0198286-A2 Analytical compositions, elements and methods utilizing reduction of ferric ion chelates to form detectable dyes EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1986-10-22 EP disclosed
EP-0193013-A2 Benzimidazolyl-pyridazinones MERCK PATENT GmbH (DE) 1986-09-03 EP disclosed
EP-0009411-B1 PHOTOGRAPHIC RECORDING MATERIAL CONTAINING POLYMERS WHICH COORDINATE WITH METAL IONS EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1983-06-01 EP disclosed
US-4299895-A Photographic elements containing polymers which coordinate with metal ions EASTMAN KODAK COMPANY (US) 1981-11-10 US disclosed
US-4239847-A Photographic elements containing polymers which coordinate with metal ions EASTMAN KODAK COMPANY (US) 1980-12-16 US disclosed
EP-0009411-A2 Photographic recording material containing polymers which coordinate with metal ions EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1980-04-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080131367-A1 Composition For Diagnosing Amyloid-Related Diseases APP, APBA1, FABP7 ALDH1A1 3190/4885APP 1/4885KCNH2 2202/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.