Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 2/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23748138 | 0.89 | SMN1; SMN2 (0.44) | SMN1; SMN2GAACYP11B1CYP11B2LMNA | |
| SCHEMBL23748286 | 0.83 | KCNA5 (0.33) | SMN1; SMN2KCNA5KCNH2CFTRGOPC | |
| SCHEMBL23748324 | 0.83 | CYP3A4 (0.36) | SMN1; SMN2GAACYP11B1CYP11B2LMNA | |
| SCHEMBL23748253 | 0.82 | MEN1 (0.39) | SMN1; SMN2LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23748180 | 0.75 | KCNA5 (0.33) | SMN1; SMN2KCNA5KCNH2CFTRGOPC | |
| SCHEMBL24834940 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2GAACYP11B1CYP11B2LMNA | |
| SCHEMBL23748218 | 0.73 | SMN1; SMN2 (0.38) | SMN1; SMN2GAACYP11B1CYP11B2LMNA | |
| SCHEMBL8530944 | 0.71 | SMN1; SMN2 (0.40) | SMN1; SMN2GAACYP11B1CYP11B2LMNA | |
| SCHEMBL3062558 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2GAACYP11B1CYP11B2LMNA | |
| SCHEMBL3064009 | 0.69 | SMN1; SMN2 (0.55) | SMN1; SMN2GAACYP11B1CYP11B2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11312727-B1 | Macrocyclic flu endonuclease inhibitors | Janssen Biopharma, Inc. (US) | 2022-04-26 | — | — | US | disclosed |
| EP-3864020-A1 | MACROCYCLIC FLU ENDONUCLEASE INHIBITORS | Janssen BioPharma, Inc. (US) | 2021-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312727-B1 | Macrocyclic flu endonuclease inhibitors | ACE, FEN1, PNP | SMN1; SMN2 3520/4885GAA 200/4885CYP11B1 598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.