⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1190713 | 0.79 | — | — | |
| SCHEMBL20739377 | 0.73 | NAALAD2 (0.38) | — | |
| SCHEMBL14877283 | 0.72 | — | — | |
| SCHEMBL23748014 | 0.68 | — | — | |
| SCHEMBL13147633 | 0.67 | — | — | |
| SCHEMBL1991395 | 0.67 | ALDH1A1 (0.37) | — | |
| SCHEMBL12868464 | 0.67 | ALDH1A1 (0.37) | — | |
| SCHEMBL9355281 | 0.67 | — | — | |
| SCHEMBL24612534 | 0.67 | — | — | |
| SCHEMBL1189982 | 0.67 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230135758-A1 | ELONGATION FACTOR 1-ALPHA INHIBITORS AND USES THEREOF | UNIV CALIFORNIA (US) | 2023-05-04 | — | — | US | disclosed |
| US-20230135758-A1 | ELONGATION FACTOR 1-ALPHA INHIBITORS AND USES THEREOF | UNIV CALIFORNIA (US) | 2023-05-04 | — | — | US | disclosed |
| WO-2021158899-A1 | ELONGATION FACTOR 1-ALPHA INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-08-12 | — | — | WO | disclosed |