Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Triethyl Phosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triethyl Phosphate SCHEMBL7162251 | 0.97 | TSHR (0.81) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL30529197 | 0.94 | TSHR (0.77) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL28610243 | 0.91 | TSHR (0.93) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL1332661 | 0.91 | TSHR (0.93) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL28023664 | 0.87 | TSHR (1.00) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL27822049 | 0.87 | TSHR (1.00) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL21887 | 0.87 | TSHR (1.00) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL1332591 | 0.87 | TSHR (1.00) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL28464376 | 0.85 | TSHR (0.81) | TSHRPPARDTP53TDP1CYP3A4 | |
| Triethyl Phosphate SCHEMBL11811931 | 0.84 | TSHR (0.93) | TSHRPPARDTP53TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11952491-B2 | Rigid polyurethane foam formulation and foam made therefrom | DOW GLOBAL TECHNOLOGIES LLC (US) | 2024-04-09 | — | — | US | disclosed |
| US-20210347989-A1 | A RIGID POLYURETHANE FOAM FORMULATION AND FOAM MADE THEREFROM | DOW GLOBAL TECHNOLOGIES LLC | 2021-11-11 | — | — | US | disclosed |
| EP-3864064-A1 | A RIGID POLYURETHANE FOAM FORMULATION AND FOAM MADE THEREFROM | Dow Global Technologies LLC (US) | 2021-08-18 | — | — | EP | disclosed |