SCHEMBL23749285

SCHEMBL23749285

CC(C)(O)COc1cc2nccc(Oc3ccc(N)c(Cl)c3)c2c2c1OCCO2

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RET P07949 14/20 0.51
KDR P35968 7/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23749550 0.88 RET (0.50) RETKDR
SCHEMBL23749389 0.88 RET (0.58) RETKDR
SCHEMBL23749560 0.85 RET (0.60) RETKDR
SCHEMBL23749341 0.81 KDR (0.61) RETKDR
SCHEMBL23770991 0.80 KDR (0.55) RETKDR
SCHEMBL23771049 0.79 KDR (0.51) RETKDR
SCHEMBL23749286 0.79 RET (0.62) RETKDR
SCHEMBL31441123 0.79 RET (0.55) RETKDR
SCHEMBL23749490 0.79 RET (0.55) RETKDR
SCHEMBL23770897 0.76 RET (0.41) RETKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 EP disclosed
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 EP disclosed