Sugi Predict

Sugi Predict / Compounds / SCHEMBL23749340

SCHEMBL23749340

SCHEMBL23749340

CN1CCN(CCCOc2cc3nccc(Oc4ccc(N)cc4F)c3c3c2OCCO3)CC1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AXL P30530 7/20 0.60
▸ RET P07949 4/20 0.55
▸ KDR P35968 4/20 0.47
▸ EGFR P00533 4/20 0.46
▸ MET P08581 4/20 0.45
▸ PLK4 O00444 2/20 0.45
▸ AURKA O14965 2/20 0.45
▸ GAK O14976 2/20 0.45
▸ RIPK2 O43353 2/20 0.45
▸ PRKAB2 O43741 2/20 0.45
▸ ERN1 O75460 2/20 0.45
▸ STK10 O94804 2/20 0.45
▸ FYN P06241 2/20 0.45
▸ YES1 P07947 2/20 0.45
▸ LYN P07948 2/20 0.45
▸ SRC P12931 2/20 0.45
▸ FER P16591 2/20 0.45
▸ MARK3 P27448 2/20 0.45
▸ MAP2K2 P36507 2/20 0.45
▸ TGFBR2 P37173 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23749500 0.93 AXL (0.59) AXLRETKDREGFRMET
SCHEMBL31441112 0.93 AXL (0.59) AXLRETKDREGFRMET
SCHEMBL23749319 0.92 AXL (0.58) AXLRETKDREGFRMET
SCHEMBL21265307 0.92 AXL (0.68) AXLRETKDREGFRMET
SCHEMBL23749499 0.91 AXL (0.55) AXLRETKDREGFRMET
SCHEMBL23749501 0.91 RET (0.56) AXLRETKDREGFRMET
SCHEMBL23749350 0.91 AXL (0.57) AXLRETKDREGFRMET
SCHEMBL23749358 0.90 RET (0.57) AXLRETKDREGFRMET
SCHEMBL31441120 0.90 RET (0.57) AXLRETKDREGFRMET
SCHEMBL23749330 0.90 AXL (0.57) AXLRETKDREGFRMET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12202835-B2 Substituted aromatic ring-linked dioxinoquinazolines and dioxinoquinolines as kinase inhibitors BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2025-01-21 — — US disclosed
US-20220002308-A1 AROMATIC RING-LINKED DIOXINO-QUINAZOLINE OR DIOXINO-QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF BEIJING SCITECH-MQ PHARMACEUTICALS LIMITED (CN) 2022-01-06 — — US disclosed
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 — — EP disclosed
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220002308-A1 AROMATIC RING-LINKED DIOXINO-QUINAZOLINE OR DIOXINO-QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF MERTK, AXL, TYRO3 AXL 2/4885RET 4/4885KDR 10/4885
US-12202835-B2 Substituted aromatic ring-linked dioxinoquinazolines and dioxinoquinolines as kinase inhibitors MERTK, AXL, TYRO3 AXL 2/4885RET 4/4885KDR 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.