Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 7/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 4/20 | 0.34 |
| ▸ | CCND3 | P30281 | 4/20 | 0.34 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23749394 | 1.00 | L3MBTL1 (0.39) | L3MBTL1ACACBHTTCTSACDK4 | |
| SCHEMBL22129320 | 0.87 | ACACB (0.41) | ACACBHTTCDK4HDAC1HDAC6 | |
| SCHEMBL22129331 | 0.87 | ACACB (0.41) | ACACBHTTCDK4HDAC1HDAC6 | |
| SCHEMBL30309559 | 0.80 | PLK4 (0.40) | CDK4HDAC1HDAC6HDAC3HDAC10 | |
| SCHEMBL2490112 | 0.80 | PLK4 (0.40) | CDK4HDAC1HDAC6HDAC3HDAC10 | |
| SCHEMBL21539413 | 0.80 | CDK4 (0.40) | ACACBCDK4CDK6CDK2CCND1 | |
| Hydrochloric Acid SCHEMBL31686442 | 0.78 | PLK4 (0.39) | CDK4HDAC1HDAC6HDAC3HDAC10 | |
| SCHEMBL31493878 | 0.77 | AAK1 (0.39) | ACACBCDK4HDAC1HDAC6HDAC3 | |
| SCHEMBL31493901 | 0.77 | AAK1 (0.39) | ACACBCDK4HDAC1HDAC6HDAC3 | |
| SCHEMBL23749547 | 0.76 | CDK4 (0.47) | CDK4HDAC1HDAC6HDAC3HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220017520-A1 | MACROCYCLIC COMPOUND AS CDK INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | Keythera (Suzhou) Pharmaceuticals Co. Ltd. (CN) | 2022-01-20 | — | — | US | disclosed |
| EP-3865488-A1 | MACROCYCLIC COMPOUND AS CDK INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | Keythera (Suzhou) Pharmaceuticals Co. Ltd. (CN) | 2021-08-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220017520-A1 | MACROCYCLIC COMPOUND AS CDK INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | CDK4, CDK7, CDKL1 | L3MBTL1 2843/4885ACACB 2705/4885HTT 4170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.