Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.47 |
| ▸ | NT5E | P21589 | 5/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23760862 | 0.94 | ABCB1 (0.49) | POLBABCB1NT5ENR1I2ALB | |
| SCHEMBL24081848 | 0.89 | POLB (0.53) | POLBGPR17ABCB1NT5ENR1I2 | |
| SCHEMBL23760751 | 0.89 | POLB (0.53) | POLBGPR17ABCB1NT5ENR1I2 | |
| SCHEMBL23760867 | 0.84 | P2RY1 (0.53) | NT5EADORA3ADORA2BADORA1 | |
| SCHEMBL24081834 | 0.84 | POLB (0.55) | POLBGPR17ABCB1NT5ENR1I2 | |
| SCHEMBL23760882 | 0.84 | NT5E (0.45) | GPR17NT5E | |
| SCHEMBL23760747 | 0.83 | NT5E (0.44) | GPR17NT5E | |
| SCHEMBL21136289 | 0.82 | NT5E (0.68) | GPR17NT5EADORA3ADORA2AADORA1 | |
| SCHEMBL21136285 | 0.82 | NT5E (0.68) | GPR17NT5EADORA3ADORA2AADORA1 | |
| SCHEMBL21136282 | 0.82 | NT5E (0.67) | GPR17NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512863-B1 | 2'-SUBSTITUTED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR RNA VIRUS TREATMENT | ATEA PHARMACEUTICALS INC (US) | 2021-12-08 | — | — | EP | disclosed |
| EP-3865136-A1 | 2'-SUBSTITUTED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR CORONA VIRUS TREATMENT | ATEA Pharmaceuticals, Inc. (US) | 2021-08-18 | — | — | EP | disclosed |