Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.58 |
| ▸ | JAK3 | P52333 | 9/20 | 0.58 |
| ▸ | JAK1 | P23458 | 7/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27838160 | 0.87 | CDK8 (0.54) | JAK2JAK3JAK1CDK8MAPK1 | |
| SCHEMBL2379731 | 0.84 | JAK3 (0.54) | JAK2JAK3JAK1MAPK1 | |
| SCHEMBL12296758 | 0.84 | JAK3 (0.62) | JAK2JAK3JAK1MAPK1 | |
| SCHEMBL2379317 | 0.84 | JAK2 (0.51) | JAK2JAK3JAK1 | |
| SCHEMBL12245475 | 0.84 | KDM4E (0.59) | JAK2JAK3JAK1MAPK1 | |
| SCHEMBL2377622 | 0.82 | JAK2 (0.54) | JAK2JAK3JAK1MAPK1MAPK9 | |
| SCHEMBL2377302 | 0.81 | JAK3 (0.62) | JAK2JAK3JAK1MAPK1 | |
| SCHEMBL2378448 | 0.81 | JAK3 (0.58) | JAK2JAK3JAK1MAPK1 | |
| SCHEMBL27855942 | 0.80 | JAK2 (0.48) | JAK2JAK3JAK1CDK8MAPK1 | |
| SCHEMBL2378715 | 0.80 | JAK3 (0.64) | JAK2JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102232076-A | Pyrrolopyrazinyl urea kinase inhibitors | HOFFMANN LA ROCHE | 2011-11-02 | — | — | CN | claimed |
| US-8012974-B2 | Pyrrolopyrazinyl urea kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2011-09-06 | — | — | US | claimed |
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | ROCHE PALO ALTO LLC | 2010-06-10 | — | — | US | claimed |
| CN-102232076-A | Pyrrolopyrazinyl urea kinase inhibitors | HOFFMANN LA ROCHE | 2011-11-02 | — | — | CN | disclosed |
| US-8012974-B2 | Pyrrolopyrazinyl urea kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2011-09-06 | — | — | US | disclosed |
| US-8012974-B2 | Pyrrolopyrazinyl urea kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2011-09-06 | — | — | US | disclosed |
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | ROCHE PALO ALTO LLC | 2010-06-10 | — | — | US | disclosed |
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | ROCHE PALO ALTO LLC | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144745-A1 | Pyrrolopyrazinyl Urea Kinase Inhibitors | JAK1, JAK3, ULK3 | JAK2 5/4885JAK3 2/4885JAK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.