ULK3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tofacitinib (SCHEMBL322753)	1.00	2/20
Tofacitinib (SCHEMBL1120705)	1.00	2/20
Tofacitinib (SCHEMBL1374185)	1.00	2/20
SCHEMBL1846276	0.78	2/20
SCHEMBL2148397	0.75	2/20
SCHEMBL353500	0.75	2/20
SCHEMBL2148365	0.72	2/20
SCHEMBL1847444	0.69	2/20
SCHEMBL1504578	0.64	2/20
SCHEMBL1855399	0.64	2/20
SCHEMBL266638	0.63	2/20
SCHEMBL2148148	0.63	2/20
Hydrochloric Acid (SCHEMBL264113)	0.62	2/20
SCHEMBL1847611	0.62	2/20
SCHEMBL2148342	0.61	2/20
SCHEMBL2105400	0.59	2/20
SCHEMBL1669713	0.58	2/20
SCHEMBL1858735	0.58	2/20
SCHEMBL352344	0.57	2/20
SCHEMBL1853077	0.57	2/20

Clinical trials — most relevant to ULK3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS)	PHASE4	RECRUITING
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
A Phase II Study of EVEROLIMUS in Patients With Primary or Relapsed Chondrosarcomas	PHASE2	SUSPENDED
Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant Glioma	PHASE1/PHASE2	COMPLETED
Everolimus for Children With Recurrent or Progressive Ependymoma	PHASE2	COMPLETED
MLN0128 in Recurrent/Metastatic Merkel Cell Carcinoma	PHASE1/PHASE2	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Study of Nelfinavir and Temsirolimus in Patients With Advanced Cancers	PHASE1	COMPLETED
Studying TAK-243 in Patients With Advanced Cancer	PHASE1	RECRUITING
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Defining the Triple Negative Breast Cancer Kinome Response to GSK1120212	EARLY_PHASE1	COMPLETED
The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory Epilepsy	EARLY_PHASE1	RECRUITING
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
Protein Intake and Step Reduction in Older Adults	nan	COMPLETED
Muscle Wasting in Cancer (MWIC)	nan	COMPLETED
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)	nan	COMPLETED
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
The Role of Fibroblast Activation in Uterine Fibroid	nan	COMPLETED
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population	nan	COMPLETED
SMYD3-Driven Metabolic Rewiring in Colorectal Liver Metastases	nan	NOT_YET_RECRUITING
Autophagy Bladder Cancer	nan	UNKNOWN
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus	nan	COMPLETED
Association Between Intakes of Protein, Calcium and Milk With Gene Expression and Linear Growth of School Aged Children	nan	COMPLETED
Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm	nan	COMPLETED
Alternate Day Fasting After Surgery for Patients Undergoing Chemotherapy	nan	RECRUITING
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
mTORC1 and Autophagy in Human Brown Adipocytes	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ULK3 binder may also engage these)

Protein	Name	Similarity
Q3U3Q1	—	1.000	Q3U3Q1 →
D3ZHP7	—	1.000	D3ZHP7 →
Q4V7Q6	—	1.000	Q4V7Q6 →
Q5ZJH6	—	1.000	Q5ZJH6 →
RPS6KA1	Ribosomal protein S6 kinase alpha-1	0.984	landscape →
Q5RCY1	—	0.984	Q5RCY1 →
Q8WP15	—	0.984	Q8WP15 →
Q9Z2B9	—	0.984	Q9Z2B9 →
Q6Z2M9	—	0.984	Q6Z2M9 →
Q80YE7	—	0.983	Q80YE7 →
Q63285	—	0.983	Q63285 →
Q852Q2	—	0.983	Q852Q2 →
Q6PFQ0	—	0.983	Q6PFQ0 →
Q91ZR4	—	0.983	Q91ZR4 →
O88764	—	0.982	O88764 →
Q9CXF7	—	0.982	Q9CXF7 →
Q9NY93	—	0.982	Q9NY93 →
P51840	—	0.982	P51840 →
DAPK1	Death-associated protein kinase 1	0.982	landscape →
P40694	—	0.981	P40694 →
P11730	—	0.981	P11730 →
Q60560	—	0.981	Q60560 →
P51839	—	0.981	P51839 →
PNCK	Calcium/calmodulin-dependent protein kinase type 1B	0.981	landscape →
Q5Z6X0	—	0.981	Q5Z6X0 →
JAK3	Tyrosine-protein kinase JAK3	0.980	landscape →
Q63531	—	0.980	Q63531 →
RPS6KA4	Ribosomal protein S6 kinase alpha-4	0.980	landscape →
Q6DEH3	—	0.980	Q6DEH3 →
P10421	—	0.980	P10421 →