Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | GALR2 | O43603 | 3/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | GALR1 | P47211 | 1/20 | 0.42 |
| ▸ | KDM6B | O15054 | 2/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968113 | 1.00 | HDAC1 (0.50) | HDAC1HDAC6GALR2PDE10AGALR1 | |
| SCHEMBL23753909 | 0.91 | ABL1 (0.48) | HDAC1HDAC6PDE10AALDH1A1CYP1A2 | |
| SCHEMBL29967980 | 0.91 | ABL1 (0.48) | HDAC1HDAC6PDE10AALDH1A1CYP1A2 | |
| SCHEMBL23763018 | 0.89 | KARS1 (0.41) | HDAC1HDAC6KDM6BKDM2BNR1I2 | |
| SCHEMBL29968202 | 0.88 | HDAC1 (0.40) | HDAC1HDAC6GALR2KDM6BKDM2B | |
| SCHEMBL23763067 | 0.88 | HDAC1 (0.40) | HDAC1HDAC6GALR2KDM6BKDM2B | |
| SCHEMBL23763310 | 0.87 | ABL1 (0.39) | HDAC1HDAC6GALR2PDE10AKDM6B | |
| SCHEMBL23763041 | 0.87 | HDAC1 (0.44) | HDAC1HDAC6KDM6BKDM2BNR1I2 | |
| SCHEMBL23763059 | 0.87 | NPY5R (0.38) | HDAC1HDAC6GALR2KDM6BKDM2B | |
| SCHEMBL29968552 | 0.87 | ABL1 (0.39) | HDAC1HDAC6GALR2PDE10AKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | claimed |
| CN-115151534-B | Inhibitors of interleukin-1 receptor associated kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof and methods of use thereof | 南京药石科技股份有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-115151534-A | Inhibitors of interleukin-1 receptor-related kinase (IRAK)/FMS-like receptor tyrosine kinase (FLT 3), pharmaceutical products thereof, and methods thereof | 南京药石科技股份有限公司 | 2022-10-04 | — | — | CN | disclosed |
| WO-2021159993-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE (IRAK) /FMS-LIKE RECEPTOR TYROSINE KINASE (FLT3), PHARMACEUTICAL PRODUCTS THEREOF, AND METHODS THEREOF | PHARMABLOCK SCIENCES (NANJING) , INC. (CN) | 2021-08-19 | — | — | WO | disclosed |