Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9471912 | 0.98 | TAAR1 (0.53) | TAAR1ADRA2AADRA2BCYP1A2CHRM2 | |
| SCHEMBL9799324 | 0.94 | TAAR1 (0.53) | TAAR1ADRA2AADRA2BCYP1A2CHRM2 | |
| SCHEMBL2376616 | 0.88 | TAAR1 (0.54) | TAAR1ADRA2AADRA2BCYP1A2CHRM2 | |
| Hydrochloric Acid SCHEMBL4599895 | 0.86 | KDM4E (0.53) | TAAR1ADRA2AADRA2BCYP1A2CHRM2 | |
| SCHEMBL13192375 | 0.83 | TAAR1 (0.50) | TAAR1ADRA2AADRA2BCYP1A2CHRM2 | |
| SCHEMBL21242119 | 0.83 | TAAR1 (0.50) | TAAR1ADRA2AADRA2BCYP1A2CHRM2 | |
| Hydrochloric Acid SCHEMBL30149000 | 0.81 | CYP1A2 (0.46) | TAAR1ADRA2AADRA2BCYP1A2CHRM2 | |
| SCHEMBL9281325 | 0.81 | TAAR1 (0.52) | TAAR1ADRA2AADRA2BCHRM2CHRM1 | |
| SCHEMBL20135772 | 0.80 | TAAR1 (0.73) | TAAR1ADRA2AADRA2BALDH1A1SMN1; SMN2 | |
| SCHEMBL20146704 | 0.80 | TAAR1 (0.73) | TAAR1ADRA2AADRA2BALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111108101-A | Novel propylamine derivatives useful for treating pain and pain-related disorders | 埃斯蒂文制药股份有限公司 | 2020-05-05 | — | — | CN | claimed |
| EP-0298703-B1 | A THIOPHENE DERIVATIVE AND PROCESS FOR PREPARING THE SAME | TANABE SEIYAKU CO., LTD. (JP) | 1991-03-06 | — | — | EP | claimed |
| CN-118974010-A | Method for decomposing polyether-ether-ketone and novel material using decomposition product obtained by the decomposition method as raw material | 国立研究开发法人产业技术综合研究所 | 2024-11-15 | — | — | CN | disclosed |
| CN-115135644-B | Preparation method and crystal form of 3-aryloxy-3-five-membered heteroaryl-propylamine compound | 漳州片仔癀药业股份有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-114206859-B | 3-Aryloxy-3-five-membered heteroaryl-propylamine compound, and crystal forms and application thereof | 上海璃道医药科技有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112654616-B | 3-aryloxy-3-aryl-propylamines and application thereof | 漳州片仔癀药业股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-115286613-B | Preparation method of duloxetine hydrochloride | 潍坊市海欣药业有限公司 | 2023-01-31 | — | — | CN | disclosed |
| CN-112566909-B | 3-aryloxy-3-five-membered heteroaryl-propylamine compound and application thereof | 上海璃道医药科技有限公司 | 2023-01-03 | — | — | CN | disclosed |
| CN-115286613-A | Preparation method of duloxetine hydrochloride | 潍坊市海欣药业有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-115135644-A | Preparation method and crystal form of 3-aryloxy-3-pentabasic heteroaryl-propylamine compound | 漳州片仔癀药业股份有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-114206859-A | 3-aryloxy-3-pentabasic heteroaryl-propylamine compound and crystal form and application thereof | 上海璃道医药科技有限公司 | 2022-03-18 | — | — | CN | disclosed |
| WO-2009130708-A2 | PREPARATION OF DULOXETINE AND ITS SALTS | SHODHANA LABORATORIES LIMITED (IN) | 2009-10-29 | — | — | WO | disclosed |
| WO-2009109992-A1 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE AND INTERMEDIATES FOR USE THEREIN | ARCH PHARMALABS LIMITED (IN) | 2009-09-11 | — | — | WO | disclosed |
| WO-2008107911-A2 | NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE | LUPIN LIMITED (IN) | 2008-09-12 | — | — | WO | disclosed |
| US-20070151910-A1 | Chromatographic material for the absorption of proteins at physiological ionic strength | PALL CORPORATION (US) | 2007-07-05 | — | — | US | disclosed |
| EP-1715948-A2 | CHROMATOGRAPHIC MATERIAL FOR THE ABSORPTION OF PROTEINS AT PHYSIOLOGICAL IONIC STRENGTH | Pall Corporation (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005073711-A2 | CHROMATOGRAPHIC MATERIAL FOR THE ABSORPTION OF PROTEINS AT PHYSIOLOGICAL IONIC STRENGTH | PALL CORPORATION (US) | 2005-08-11 | — | — | WO | disclosed |
| US-4506007-A | TREATED WITH N,N'-DISUBSTITUTED-S-(DIMETHYLAMINO) ETHYTL)-ISOTHIOUREAS | FUJI PHOTO FILM CO., LTD. (JP) | 1985-03-19 | — | — | US | disclosed |
| US-4264618-A | Basic thio-indazoles | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1981-04-28 | — | — | US | disclosed |
| US-4000188-A | ANIONIC SURFACTANTS | CIBA-GEIGY CORPORATION (US) | 1976-12-28 | — | — | US | disclosed |