⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18560225 | 1.00 | — | — | |
| SCHEMBL23060170 | 0.78 | — | — | |
| SCHEMBL14547331 | 0.74 | — | — | |
| SCHEMBL12593258 | 0.71 | — | — | |
| SCHEMBL20078267 | 0.71 | — | — | |
| SCHEMBL20627350 | 0.71 | — | — | |
| SCHEMBL21386217 | 0.71 | — | — | |
| SCHEMBL18912145 | 0.70 | IMPDH2 (0.31) | — | |
| SCHEMBL24405764 | 0.70 | — | — | |
| SCHEMBL12445585 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159508-A1 | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2023-05-25 | — | — | US | disclosed |
| EP-3985010-A1 | SPIROCYCLIC INHIBITORS OF HEPATITIS B VIRUS | Promidis S.r.l. (IT) | 2022-04-20 | — | — | EP | disclosed |
| EP-3865489-A1 | SPIROCYCLIC INHIBITORS OF HEPATITIS B VIRUS | Promidis S.r.l. (IT) | 2021-08-18 | — | — | EP | disclosed |