Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 12/20 | 0.67 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.59 |
| ▸ | INSR | P06213 | 3/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ULK1 | O75385 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23764832 | 0.96 | MET (0.67) | METALKPKMYT1INSRMAPK8 | |
| SCHEMBL30086179 | 0.90 | MET (0.66) | METALKINSRMAPK8MAPK9 | |
| SCHEMBL23754872 | 0.90 | MET (0.66) | METALKINSRMAPK8MAPK9 | |
| SCHEMBL23754864 | 0.88 | MET (0.64) | METALKINSRULK1PTK2 | |
| SCHEMBL30086189 | 0.88 | MET (0.64) | METALKINSRULK1PTK2 | |
| SCHEMBL23764799 | 0.88 | MET (0.61) | METALKPKMYT1INSRMAPK8 | |
| SCHEMBL30086206 | 0.87 | MET (0.66) | METALKINSRMAPK8MAPK9 | |
| SCHEMBL23754821 | 0.87 | MET (0.66) | METALKINSRMAPK8MAPK9 | |
| SCHEMBL886191 | 0.85 | MET (0.79) | METALKPKMYT1INSRMAPK8 | |
| SCHEMBL886346 | 0.83 | MET (0.69) | METALKPKMYT1INSRPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021163629-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2021-08-19 | — | — | WO | disclosed |