⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24202 | 0.78 | TSHR (0.48) | — | |
| SCHEMBL44447 | 0.77 | TSHR (0.44) | — | |
| SCHEMBL29507678 | 0.77 | TSHR (0.44) | — | |
| SCHEMBL1162903 | 0.77 | TSHR (0.44) | — | |
| SCHEMBL2588514 | 0.74 | TSHR (0.57) | — | |
| SCHEMBL4781181 | 0.73 | TSHR (0.62) | — | |
| SCHEMBL109650 | 0.67 | CYP1A2 (0.62) | — | |
| SCHEMBL33555 | 0.67 | — | — | |
| SCHEMBL22081972 | 0.67 | CYP1A2 (0.62) | — | |
| SCHEMBL29351986 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4830 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432995-B1 | — | — | None | — | — | US | claimed |
| CN-115611856-B | Piperidine derivative and pharmaceutical composition, preparation method and application thereof | 宜昌人福药业有限责任公司 | 2024-07-05 | — | — | CN | claimed |
| US-12018021-B2 | Thiophene derivatives for the treatment of disorders caused by IgE | UCB Biopharma SRL (BE) | 2024-06-25 | — | — | US | claimed |
| CN-117836296-A | Pyrazolopyridone compounds | 百济神州有限公司 | 2024-04-05 | — | — | CN | claimed |
| EP-4345096-A1 | PIPERIDINE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF | Yichang Humanwell Pharmaceutical Co., Ltd. (CN) | 2024-04-03 | — | — | EP | claimed |
| CN-117642402-A | Spiropiperidine ring derivative and pharmaceutical composition, preparation method and application thereof | 宜昌人福药业有限责任公司 | 2024-03-01 | — | — | CN | claimed |
| CN-117642389-A | Piperidine derivative and pharmaceutical composition, preparation method and application thereof | 宜昌人福药业有限责任公司 | 2024-03-01 | — | — | CN | claimed |
| US-20230416205-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | TENVIE THERAPEUTICS, INC. | 2023-12-28 | — | — | US | claimed |
| CN-117143002-A | Preparation method of indolinyl acetone | 浙江工业大学 | 2023-12-01 | — | — | CN | claimed |
| US-20230365524-A1 | 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONES USEFUL AS INHIBITORS OF DHODH | BAYER AKTIENGESELLSCHAFT (DE) | 2023-11-16 | — | — | US | claimed |
| US-4472383-A | HYPOTENSIVE AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-09-18 | — | — | US | claimed |
| US-4472381-A | Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them | AJINOMOTO COMPANY INCORPORATED (JP) | 1984-09-18 | — | — | US | claimed |
| US-4468245-A | N-(2,3-Epoxypropylene)-n-aralkylsulfonamide and herbicidal compositions containing the same | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JP) | 1984-08-28 | — | — | US | claimed |
| EP-0104546-A2 | Therapeutic dipeptides | USV PHARMACEUTICAL CORPORATION (US) | 1984-04-04 | — | — | EP | claimed |
| EP-0092942-A2 | Peptide derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-02 | — | — | EP | claimed |
| EP-0085488-A2 | Amino acid derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1983-08-10 | — | — | EP | claimed |
| US-4256761-A | Antihypertensive amides | USV PHARMACEUTICAL CORPORATION (US) | 1981-03-17 | — | — | US | claimed |
| US-4152527-A | 15-Substituted-ω-pentanorprostaglandins | PFIZER INC. (US) | 1979-05-01 | — | — | US | claimed |
| US-4136185-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS, ADRENOLYTICS, ANTIPHLOGISTICS, ANALGESICS, ANTIHISTAMINES, ANTICHOLESTEROL AGENTS | BOEHRINGER INGELHEIM GMBH (DE) | 1979-01-23 | — | — | US | claimed |
| US-3998834-A | ANALGESICS | JANSSEN PHARMACEUTICA N.V. (BE) | 1976-12-21 | — | — | US | claimed |