SCHEMBL23766301

SCHEMBL23766301

O=CNCCCNCCCCCC(=O)Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 12/20 0.52
▸ BRD4 O60885 12/20 0.52
▸ DDB1 Q16531 3/20 0.52
▸ MAP1LC3B Q9GZQ8 1/20 0.51
▸ CSNK1A1 P48729 1/20 0.49
▸ IKZF1 Q13422 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23766284 0.91 CRBN (0.53) CRBNBRD4DDB1IKZF1
SCHEMBL25031675 0.91 CRBN (0.53) CRBNBRD4DDB1IKZF1
SCHEMBL26323874 0.91 CRBN (0.63) CRBNBRD4DDB1MAP1LC3BCSNK1A1
SCHEMBL26323878 0.91 CRBN (0.63) CRBNBRD4DDB1MAP1LC3BCSNK1A1
SCHEMBL26321035 0.91 CRBN (0.63) CRBNBRD4DDB1MAP1LC3BCSNK1A1
SCHEMBL26317744 0.91 CRBN (0.63) CRBNBRD4DDB1MAP1LC3BCSNK1A1
SCHEMBL25031672 0.91 STAT3 (0.51) CRBNBRD4DDB1MAP1LC3B
SCHEMBL25031775 0.90 BRD4 (0.55) CRBNBRD4DDB1MAP1LC3B
SCHEMBL18666868 0.90 CRBN (0.56) CRBNBRD4DDB1MAP1LC3BIKZF1
SCHEMBL23766094 0.90 STAT3 (0.52) CRBNBRD4DDB1MAP1LC3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4134104-A1 TARGETED PROTEASE DEGRADATION (TED) PLATFORM Eubulus Biotherapeutics Inc. (CN) 2023-02-15 — — EP disclosed
EP-3865152-A1 TARGETED PROTEASE DEGRADATION PLATFORM Eubulus Biotherapeutics Inc. (CN) 2021-08-18 — — EP disclosed
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