Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.68 |
| ▸ | CDK1 | P06493 | 1/20 | 0.68 |
| ▸ | CDK4 | P11802 | 19/20 | 0.67 |
| ▸ | CCND1 | P24385 | 17/20 | 0.67 |
| ▸ | CCND3 | P30281 | 10/20 | 0.67 |
| ▸ | CCND2 | P30279 | 9/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.67 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.66 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.66 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.66 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.64 |
| ▸ | FECH | P22830 | 1/20 | 0.64 |
| ▸ | CDK9 | P50750 | 1/20 | 0.64 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.64 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.64 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19055321 | 0.97 | CDK4 (0.70) | CDK2CDK4CCND1CCND3CCND2 | |
| SCHEMBL19980555 | 0.86 | CDK4 (0.73) | CDK2CDK4CCND1CCND3CCND2 | |
| SCHEMBL1990685 | 0.82 | CDK2 (0.73) | CDK2CDK1CDK4CCND1CCND3 | |
| SCHEMBL1993460 | 0.81 | CDK2 (1.00) | CDK2CDK1CDK4CCND1CCND3 | |
| SCHEMBL25005415 | 0.80 | CDK4 (0.73) | CDK2CDK1CDK4CCND1CCND3 | |
| SCHEMBL6222296 | 0.80 | CDK4 (1.00) | CDK2CDK4CCND1CCND3CCND2 | |
| SCHEMBL23837859 | 0.80 | CDK4 (0.83) | CDK2CDK1CDK4CCND1CCND3 | |
| SCHEMBL20677024 | 0.80 | CDK4 (1.00) | CDK2CDK4CCND1CCND3CCND2 | |
| Hydrochloric Acid SCHEMBL4446125 | 0.80 | CDK4 (1.00) | CDK2CDK4CCND1CCND3CCND2 | |
| Hydrochloric Acid SCHEMBL29507461 | 0.80 | CDK4 (1.00) | CDK2CDK4CCND1CCND3CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210253578-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | ASTEX THERAPEUTICS LTD. (GB) | 2021-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210253578-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | CDK6, CDK8, CDK7 | CDK2 7/4885CDK1 6/4885CDK4 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.