Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.73 |
| ▸ | CCND1 | P24385 | 18/20 | 0.73 |
| ▸ | CCND3 | P30281 | 10/20 | 0.73 |
| ▸ | CCND2 | P30279 | 9/20 | 0.73 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.73 |
| ▸ | CDK2 | P24941 | 7/20 | 0.73 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.73 |
| ▸ | FGFR2 | P21802 | 7/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 7/20 | 0.73 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.73 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.72 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.69 |
| ▸ | FECH | P22830 | 1/20 | 0.69 |
| ▸ | CDK9 | P50750 | 1/20 | 0.69 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.69 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.69 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.69 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19055321 | 0.89 | CDK4 (0.70) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL23767757 | 0.86 | CDK2 (0.68) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL19711448 | 0.86 | CDK4 (0.56) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6221730 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL29507453 | 0.85 | CDK4 (0.81) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6222296 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6221400 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL2685016 | 0.85 | CDK4 (0.81) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL6222070 | 0.85 | CDK4 (1.00) | CDK4CCND1CCND3CCND2CCNA2 | |
| SCHEMBL4833026 | 0.84 | CDK4 (1.00) | CDK4CCND1CCND3CCND2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4005573-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | Novartis AG (CH) | 2022-06-01 | — | — | EP | disclosed |
| EP-3340990-B1 | PHARMACEUTICAL COMBINATIONS COMPRISING (A) THE CYCLIN DEPENDENT KINASE 4/6 (CDK4/6) INHIBITOR LEE011 (=RIBOCICLIB), AND (B) THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) INHIBITOR ERLOTINIB, FOR THE TREATMENT OR PREVENTION OF CANCER | NOVARTIS AG (CH) | 2019-09-25 | — | — | EP | disclosed |
| EP-3038652-B1 | COMBINATION OF AN ALK INHIBITOR AND A CDK INHIBITOR FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | NOVARTIS AG (CH) | 2018-03-21 | — | — | EP | disclosed |