SCHEMBL23769022

SCHEMBL23769022

O=C(Nc1ccc(F)cc1)Nc1ccc2c(c1)N(Cc1ccncc1)C(=O)CS2

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.56
MEN1 O00255 6/20 0.56
KMT2A Q03164 6/20 0.56
HTT P42858 3/20 0.53
SMN1; SMN2 Q16637 3/20 0.53
OPRM1 P35372 1/20 0.53
OPRD1 P41143 1/20 0.53
TSHR P16473 2/20 0.52
ALDH1A1 P00352 3/20 0.52
TP53 P04637 3/20 0.52
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
POLB P06746 1/20 0.50
USP2 O75604 3/20 0.48
MAPK1 P28482 3/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
TAAR1 Q96RJ0 2/20 0.47
NPC1 O15118 2/20 0.47
LMNA P02545 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23768798 0.90 TSHR (0.60) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL23769074 0.89 MAPT (0.53) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL29979355 0.89 MAPT (0.53) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL23769024 0.89 USP2 (0.61) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL23768800 0.83 MAPT (0.58) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL23769025 0.82 TSHR (0.60) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL23768799 0.80 USP2 (0.60) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL29979360 0.80 USP2 (0.60) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL25037517 0.80 STING1 (0.46) MAPTMEN1KMT2AHTTSMN1; SMN2
SCHEMBL30191932 0.80 STING1 (0.46) MAPTMEN1KMT2AHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115151304-B Small molecule interferon gene stimulating factor (STING) antagonists 库拉德夫制药私人有限公司 2025-02-11 CN claimed
CN-115151304-A Small molecule interferon gene stimulating factor (STING) antagonists 库拉德夫制药私人有限公司 2022-10-04 CN claimed
US-20230124361-A1 SMALL MOLECULE STING ANTAGONISTS CURADEV PHARMA PVT. LTD. (IN) 2023-04-20 US disclosed
US-20230124361-A1 SMALL MOLECULE STING ANTAGONISTS CURADEV PHARMA PVT. LTD. (IN) 2023-04-20 US disclosed
WO-2021161230-A1 SMALL MOLECULE STING ANTAGONISTS CURADEV PHARMA PVT. LTD. (IN) 2021-08-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230124361-A1 SMALL MOLECULE STING ANTAGONISTS STING1, CGAS, MAVS MAPT 3716/4885MEN1 1700/4885KMT2A 4579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.