Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.41 |
| ▸ | RBP4 | P02753 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23773116 | 1.00 | BTK (0.44) | BTKKLKB1RBP4NOTUMHPGD | |
| SCHEMBL23769202 | 0.88 | BTK (0.42) | BTKKLKB1NOTUM | |
| SCHEMBL23768861 | 0.87 | BTK (0.47) | BTKKLKB1RBP4 | |
| SCHEMBL23769320 | 0.86 | NOTUM (0.42) | BTKKLKB1NOTUMKMT2A | |
| SCHEMBL18795065 | 0.85 | BTK (0.57) | BTKKLKB1HPGDSMN1; SMN2 | |
| SCHEMBL18815275 | 0.82 | BTK (0.57) | BTKKLKB1 | |
| SCHEMBL21736670 | 0.80 | KLKB1 (0.56) | BTKKLKB1NOTUMHPGDSMN1; SMN2 | |
| SCHEMBL23769406 | 0.79 | KLKB1 (0.48) | KLKB1NOTUMKMT2A | |
| SCHEMBL23769313 | 0.79 | KLKB1 (0.48) | KLKB1NOTUMHPGDKMT2A | |
| SCHEMBL23769142 | 0.79 | KLKB1 (0.44) | KLKB1RBP4NOTUMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |