Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23843107 | 0.83 | KLKB1 (0.49) | KLKB1KDM4E | |
| SCHEMBL23769679 | 0.80 | KLKB1 (0.49) | KLKB1KDM4EPDE10A | |
| SCHEMBL23769291 | 0.75 | KLKB1 (0.35) | KLKB1 | |
| SCHEMBL22166223 | 0.74 | KLKB1 (0.54) | KLKB1KDM4EL3MBTL1 | |
| SCHEMBL23769168 | 0.72 | KLKB1 (0.46) | KLKB1KDM4E | |
| SCHEMBL23769680 | 0.71 | KLKB1 (0.40) | KLKB1KDM4EL3MBTL1 | |
| SCHEMBL21736749 | 0.70 | KLKB1 (0.61) | KLKB1KDM4E | |
| SCHEMBL22166215 | 0.70 | KLKB1 (0.61) | KLKB1 | |
| SCHEMBL23769169 | 0.69 | KLKB1 (0.48) | KLKB1KDM4E | |
| SCHEMBL21736748 | 0.69 | KLKB1 (0.58) | KLKB1KDM4EPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |