Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 6/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23769658 | 0.88 | GRM2 (0.35) | GRM2KLKB1 | |
| SCHEMBL23753977 | 0.86 | KLKB1 (0.42) | GRM2KLKB1DPP4DPP8DPP9 | |
| SCHEMBL23768933 | 0.83 | KLKB1 (0.46) | KLKB1 | |
| SCHEMBL23769290 | 0.81 | KLKB1 (0.39) | GRM2KLKB1 | |
| SCHEMBL23769504 | 0.81 | NOTUM (0.39) | KLKB1ALDH1A1TDP1HPGDALOX15 | |
| SCHEMBL23769210 | 0.80 | KLKB1 (0.38) | GRM2KLKB1 | |
| SCHEMBL23754334 | 0.78 | KLKB1 (0.43) | GRM2KLKB1DPP4DPP8DPP9 | |
| SCHEMBL3089096 | 0.78 | KLKB1 (0.54) | GRM2KLKB1DPP4DPP8DPP9 | |
| SCHEMBL23754004 | 0.77 | KLKB1 (0.42) | GRM2KLKB1DPP4DPP8DPP9 | |
| SCHEMBL29906584 | 0.77 | KLKB1 (0.42) | GRM2KLKB1DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |