Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | GBA1 | P04062 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753983 | 0.84 | KLKB1 (0.37) | GFERKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL29906540 | 0.84 | KLKB1 (0.37) | GFERKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL23753981 | 0.84 | KLKB1 (0.37) | GFERKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL23768952 | 0.80 | GFER (0.38) | GFERKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL23769214 | 0.70 | MAP3K12 (0.30) | — | |
| SCHEMBL8802519 | 0.68 | KDM4E (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8802527 | 0.68 | KDM4E (0.44) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL23768790 | 0.66 | KLKB1 (0.36) | — | |
| SCHEMBL24918819 | 0.66 | KLKB1 (0.48) | — | |
| SCHEMBL21861490 | 0.63 | ACACB (0.37) | ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |