Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 9/20 | 0.37 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23753983 | 1.00 | KLKB1 (0.37) | KLKB1GFERKDM4EALDH1A1LMNA | |
| SCHEMBL23753981 | 1.00 | KLKB1 (0.37) | KLKB1GFERKDM4EALDH1A1LMNA | |
| SCHEMBL23768952 | 0.85 | GFER (0.38) | KLKB1GFERKDM4EALDH1A1LMNA | |
| SCHEMBL23769691 | 0.84 | GFER (0.34) | GFERKDM4EALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL31033243 | 0.78 | KLKB1 (0.36) | KLKB1GFERKDM4EALDH1A1MEN1 | |
| SCHEMBL21713091 | 0.78 | KLKB1 (0.36) | KLKB1GFERKDM4EALDH1A1MEN1 | |
| SCHEMBL29906594 | 0.73 | KLKB1 (0.46) | KLKB1ACACB | |
| SCHEMBL23754000 | 0.73 | KLKB1 (0.46) | KLKB1ACACB | |
| SCHEMBL23843164 | 0.72 | KLKB1 (0.37) | KLKB1KDM4EALDH1A1 | |
| SCHEMBL8802519 | 0.70 | KDM4E (0.44) | KDM4EALDH1A1LMNAMEN1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116120287-B | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-116120287-A | Heteroaromatic carboxamide derivatives as inhibitors of plasma kallikrein | 勃林格殷格翰国际有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-115052873-A | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | 勃林格殷格翰国际有限公司 | 2022-09-13 | — | — | CN | disclosed |