Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | MPL | P40238 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
| ▸ | PDE6A | P16499 | 1/20 | 0.34 |
| ▸ | PDE6G | P18545 | 1/20 | 0.34 |
| ▸ | PDE6B | P35913 | 1/20 | 0.34 |
| ▸ | PDE6C | P51160 | 1/20 | 0.34 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464862 | 0.85 | HSD11B1 (0.39) | HSD11B1MPLADORA2AADORA1PDE2A | |
| SCHEMBL19968792 | 0.85 | MPL (0.44) | HSD11B1MPLADORA2AADORA1PDE2A | |
| SCHEMBL19927801 | 0.85 | HSD11B1 (0.39) | HSD11B1MPLADORA2AADORA1PDE2A | |
| SCHEMBL29464894 | 0.78 | TRPV1 (0.44) | HSD11B1MPLNOTUM | |
| SCHEMBL19968793 | 0.78 | TRPV1 (0.44) | HSD11B1MPLNOTUM | |
| SCHEMBL19925692 | 0.72 | SCN1A (0.38) | HSD11B1 | |
| SCHEMBL29464850 | 0.72 | SCN1A (0.38) | HSD11B1 | |
| SCHEMBL23770752 | 0.72 | MPL (0.34) | HSD11B1MPL | |
| SCHEMBL173020 | 0.69 | HSD11B1 (0.45) | HSD11B1MPLNOTUMKCNN4TDP1 | |
| Ammonia Solution, Strong SCHEMBL28723095 | 0.68 | HSD11B1 (0.44) | HSD11B1MPLNOTUMKCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |