Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 14/20 | 0.39 |
| ▸ | HTR2A | P28223 | 7/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 9/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770846 | 0.88 | HTR2C (0.35) | HTR2CHTR2AHTR2BCCNT1CCNK | |
| SCHEMBL23770663 | 0.86 | CYP1A2 (0.43) | HTR2C | |
| SCHEMBL29464303 | 0.83 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| SCHEMBL19951341 | 0.83 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| SCHEMBL19951343 | 0.83 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| SCHEMBL19968833 | 0.83 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| SCHEMBL29464512 | 0.83 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| Hydrochloric Acid SCHEMBL19951372 | 0.82 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| Hydrochloric Acid SCHEMBL29464901 | 0.82 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 | |
| Hydrochloric Acid SCHEMBL19951374 | 0.82 | HTR2C (0.40) | HTR2CHTR2AKCNH2HTR2BPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |