Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.35 |
| ▸ | HTR2B | P41595 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 6/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.31 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.31 |
| ▸ | ITGAL | P20701 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23770845 | 0.88 | HTR2C (0.39) | HTR2CHTR2BHTR2ACCNT1CCNK | |
| SCHEMBL29464547 | 0.84 | HTR2C (0.34) | HTR2CHTR2BHTR2AFPR2SCN9A | |
| SCHEMBL29464465 | 0.84 | HTR2C (0.34) | HTR2CHTR2BHTR2AFPR2SCN9A | |
| SCHEMBL29464957 | 0.84 | HTR2C (0.34) | HTR2CHTR2BHTR2AFPR2SCN9A | |
| SCHEMBL19925202 | 0.84 | HTR2C (0.34) | HTR2CHTR2BHTR2AFPR2SCN9A | |
| SCHEMBL19927715 | 0.84 | HTR2C (0.34) | HTR2CHTR2BHTR2AFPR2SCN9A | |
| SCHEMBL23770700 | 0.83 | HDAC6 (0.36) | — | |
| SCHEMBL23770663 | 0.83 | CYP1A2 (0.43) | HTR2C | |
| SCHEMBL23770806 | 0.82 | RBP4 (0.36) | ITGB2ICAM1ITGAL | |
| SCHEMBL23770674 | 0.81 | MPL (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504194-B1 | N-(PYRIDIN-2-YL)PYRIDINE-SULFONAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2021-08-18 | — | — | EP | disclosed |