SCHEMBL23770925

SCHEMBL23770925

CCn1cc(C(=O)Nc2ccc(Oc3cccc4cc(OCC(C)(C)O)c5c(c34)OCCO5)cc2)c(=O)n(-c2ccc(F)cc2)c1=O

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AXL P30530 17/20 0.53
MET P08581 11/20 0.52
MERTK Q12866 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23749320 0.90 MET (0.58) AXLMETMERTK
SCHEMBL23749537 0.82 MET (0.63) AXLMETMERTK
SCHEMBL23749555 0.81 AXL (0.67) AXLMET
SCHEMBL23749415 0.81 MET (0.64) AXLMET
SCHEMBL23749343 0.79 MET (0.59) AXLMET
SCHEMBL23749308 0.78 AXL (0.61) AXLMET
SCHEMBL23749376 0.75 MET (0.62) AXLMETMERTK
SCHEMBL23749291 0.75 MET (0.72) AXLMET
SCHEMBL23749425 0.75 MET (0.75) AXLMETMERTK
SCHEMBL23749274 0.74 MET (0.68) AXLMETMERTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 EP disclosed