SCHEMBL23770928

SCHEMBL23770928

CCn1cc(C(=O)NC2=CC=C(Oc3ccnc4cc(OC)c5c(c34)OCCO5)CC2)c(=O)n(-c2ccc(F)cc2)c1=O

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MET P08581 18/20 0.60
AXL P30530 13/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23770929 0.90 MET (0.59) METAXL
SCHEMBL23749555 0.88 AXL (0.67) METAXL
SCHEMBL23749291 0.88 MET (0.72) METAXL
SCHEMBL23749563 0.85 MET (0.76) METAXL
SCHEMBL23749565 0.85 MET (0.62) METAXL
SCHEMBL23749415 0.83 MET (0.64) METAXL
SCHEMBL23749425 0.82 MET (0.75) METAXL
SCHEMBL23749373 0.81 MET (0.69) METAXL
SCHEMBL23749296 0.81 MET (0.70) METAXL
SCHEMBL23749364 0.81 MET (0.71) METAXL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3865487-A1 AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF Beijing Scitech-MQ Pharmaceuticals Limited (CN) 2021-08-18 EP disclosed