Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.57 |
| ▸ | KDR | P35968 | 6/20 | 0.56 |
| ▸ | EGFR | P00533 | 5/20 | 0.46 |
| ▸ | RAF1 | P04049 | 3/20 | 0.45 |
| ▸ | BRAF | P15056 | 3/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23749286 | 0.88 | RET (0.62) | RETKDREGFRRAF1BRAF | |
| SCHEMBL21265689 | 0.88 | RET (0.58) | RETKDREGFRRAF1BRAF | |
| SCHEMBL21246991 | 0.87 | RET (0.62) | RETKDREGFRRAF1BRAF | |
| SCHEMBL22769725 | 0.83 | RET (0.60) | RETKDREGFRRAF1BRAF | |
| SCHEMBL31441123 | 0.81 | RET (0.55) | RETKDREGFRRAF1BRAF | |
| SCHEMBL23749490 | 0.81 | RET (0.55) | RETKDREGFRRAF1BRAF | |
| SCHEMBL21246971 | 0.80 | RET (0.57) | RETKDREGFRRAF1BRAF | |
| SCHEMBL22779035 | 0.79 | KDR (0.61) | RETKDREGFRRAF1BRAF | |
| SCHEMBL21262883 | 0.79 | KDR (0.70) | RETKDRRAF1BRAF | |
| SCHEMBL23749528 | 0.79 | RET (0.60) | RETKDREGFRRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3865487-A1 | AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-08-18 | — | — | EP | disclosed |