Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.55 |
| ▸ | MET | P08581 | 8/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | AXL | P30530 | 5/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.49 |
| ▸ | MERTK | Q12866 | 3/20 | 0.49 |
| ▸ | MST1R | Q04912 | 6/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | ABL2 | P42684 | 1/20 | 0.48 |
| ▸ | FRK | P42685 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23749571 | 0.87 | MET (0.70) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23749381 | 0.85 | MET (0.70) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23749556 | 0.83 | MET (0.73) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23749527 | 0.83 | MET (0.67) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23749421 | 0.82 | MET (0.68) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23749407 | 0.82 | MET (0.64) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23771033 | 0.81 | MET (0.65) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23749561 | 0.81 | MET (0.77) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23770933 | 0.81 | MET (0.49) | RETMETKDRAXLTYRO3 | |
| SCHEMBL23749375 | 0.81 | MET (0.70) | RETMETKDRAXLTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3865487-A1 | AROMATIC RING-LINKED DIOXANE-QUINAZOLINE OR -QUINOLINE COMPOUNDS, COMPOSITIONS AND USE THEREOF | Beijing Scitech-MQ Pharmaceuticals Limited (CN) | 2021-08-18 | — | — | EP | disclosed |