Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.33 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.33 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30823749 | 0.74 | GSK3B (0.42) | KDM4EMAPTGSK3BAXLHTR2A | |
| SCHEMBL22890269 | 0.72 | GSK3B (0.46) | KDM4EGAAMAPTGSK3BAXL | |
| SCHEMBL31422750 | 0.72 | GSK3B (0.46) | KDM4EGAAMAPTGSK3BAXL | |
| SCHEMBL25274990 | 0.69 | GSK3B (0.43) | KDM4EGAAMAPTGSK3BAXL | |
| SCHEMBL2471366 | 0.69 | GSK3B (0.47) | KDM4EMAPTGSK3BAXLHTR2A | |
| SCHEMBL23108393 | 0.66 | GSK3B (0.43) | KDM4EGAAMAPTGSK3BAXL | |
| SCHEMBL3148559 | 0.65 | HTR1D (0.58) | GSK3BAXLPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL118573 | 0.63 | JAK2 (0.64) | KDM4EGAAMAPTGSK3BAXL | |
| SCHEMBL2776414 | 0.63 | MAPT (0.70) | KDM4EGAAMAPTCHRNB4CHRNA3 | |
| SCHEMBL30197402 | 0.63 | MAPT (0.83) | KDM4EGAAMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021163633-A1 | MONO AND COMBINATION THERAPIES WITH ULK1/2 INHIBITORS | SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2021-08-19 | — | — | WO | disclosed |