Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23778420 | 0.91 | HRH3 (0.40) | HRH3KCNH2ALDH1A1 | |
| SCHEMBL20066025 | 0.89 | HRH3 (0.46) | HRH3PKMIRAK4ALDH1A1 | |
| SCHEMBL20066227 | 0.88 | HRH3 (0.45) | HRH3KCNH2IRAK4ALDH1A1 | |
| SCHEMBL23778350 | 0.87 | HRH3 (0.39) | HRH3KCNH2IRAK4 | |
| SCHEMBL20066036 | 0.86 | HRH3 (0.43) | HRH3KCNH2IRAK4ALDH1A1 | |
| SCHEMBL20066037 | 0.85 | HRH3 (0.43) | HRH3KCNH2IRAK4ALDH1A1TSHR | |
| SCHEMBL23778387 | 0.85 | HRH3 (0.43) | HRH3KCNH2 | |
| SCHEMBL23778451 | 0.85 | HRH3 (0.40) | HRH3KCNH2IRAK4 | |
| SCHEMBL23778281 | 0.85 | HRH3 (0.45) | HRH3KCNH2 | |
| SCHEMBL23778270 | 0.85 | ALDH1A1 (0.46) | HRH3PKMALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3526207-B1 | HETEROCYCLIC COMPOUNDS HAVING ACTIVITY AS MODULATORS OF MUSCARINIC M1 AND/OR M4 RECEPTORS IN THE TREATMENT OF CNS DISEASES AND PAINS. | HEPTARES THERAPEUTICS LTD (GB) | 2021-09-08 | — | — | EP | claimed |